Objective : To purpose of the this study was to investigate the effect of depression, cognitive function, and activities of daily living on quality of life for patients with stroke. Methods : This study was conducted at K hospital located in Daegu, inpatients or outpatients in 50 stroke patients. Appropriate selection criteria for the study subjects who study subjects to evaluate the cognitive function, activities of daily living. General characteristic, depression and quality of life were examined through a questionnaire, which was in the final analysis. Results : Factors that affect the quality of life of the correlation as a result of negatively correlated with their depression(r=-.460, p<.01), age(r=-.481, p<.001), cognitive function(r=.458, p<.01), activities of daily living(r=.560, p<.001), education standard(r=.338, p<.05) was found in the positively correlated. Finally, the effect on quality of life for patients with stroke in variables affecting depression(β=-.253, p<.05), age(β=-.272, p<.05), and activities of daily living (β=.279, p<.05) were the order of analysis. Conclusion : Through this study result, depression and activities of daily living that affect their quality of life has been identified as the main variable.