Purpose : The purpose of this study was to know the relationship of stress and aggression of children with physical disability. The study also tried to search the factors affecting aggression and offer the information to the department of occupational therapy for intervention. Method : We distributed questionnaire to 105 children who have disability grades from hospitals in Gyeongsangbukdo, Gyeongsangnamdo, Daegu, and Busan and collected the data. We used descriptives for analysis of general characteristics, t-test and one-way ANOVA for stress and aggression according to characteristics, and Pearson correlation coefficient and stepwise regression for stress and aggression. Result : The first, stress score was 2.65, aggression was 2.53, and physical aggression was 3.01 that is the highest score in the items. The second, there was a significant difference of physical aggression(p=.021) in comparison of the grades. There was a significant difference of stress(p=.048), total aggression(p=.040), and physical aggression(p=.047) in comparison of gender. There was significant difference of stress(p=.035) and total aggression(p=.042) in satisfaction of school. The third, there was a significant correlation of total aggression(r=.475), physical aggression(r=.568), language aggression(r=.311), anger(r=.397), and hostility (r=.491) quantitatively in correlation of stress and aggression. The fourth, the factors affecting aggression of children with physical disability were stress, male, and satisfaction of school(F=61.187, p<.01). Conclusion : We knew that factors affecting aggression of children with physical disability were their stress and some of general characteristics.