Objective : The purpose of this study was to investigate the effects of employment-related attitudes of people with brain lesions, such as degree of family support for employment, self-efficacy, self-esteem, and degree of disabilities acceptance on their social participation. Methods : 281 people with brain lesions who responded as brain lesions disorder in the second wave of the forth data of Panel Survey of Employment for Disabled were selected as the study subjects. Pearson's correlation coefficient was analyzed to identify variables that could predict social participation relating to employment-related attitudes. Finally, multiple linear regression analysis was performed to investigate the effect of each variable on social participation. Results : The correlations of the variables affecting social participation of persons with brain lesions were analyzed, resulting that self-efficacy (p<.001), degree of family support for employment (p<.001), degree of disabilities acceptance (p<.05), education level (p<.01), and degree of disabilities acceptance (p<.001) turned out to have positive correlation. Among the factors of employment-related attitude of people with brain lesions, it was analyzed that degree of family support for employment (p<.001), degree of disabilities acceptance (p<.001), and self-efficacy (p<.001) accounted for 20.7% of social participation. Conclusion : Among the factors of the employment-related attitude of people with brain lesions, degree of family support for employment and self-efficacy were analyzed as important variables affecting social participation. In the future, when applying occupational therapy interventions to improve social participation, degree of family support for employment and self-efficacy should be taken into consideration.