Objective : The purpose of this study is to identify predictive factors that affect depression in stroke patients, and to provide basic data on the need to approach the occupational therapy intervention program in stroke patients by considering psychological factors such as alleviation of depression. Method : In order to identify predictive factors affecting depression in stroke patients, a secondary analysis was conducted on 91 stroke patients using data from the second year of the 8th National Health and Nutrition Examination Survey. We analyzed general characteristics, health-related characteristics, and stroke-related characteristics were in order to identify predictors of stroke patients. Depression was measured using the Korean version of the Depression Screening Tool(PHQ-9). Result : The prevalence of depression among stroke patients was 11.6%. Among the characteristics of stroke patients, there was a significant difference in marital status among general characteristics, activity restriction, perception of usual stress, and limitation of daily living activities among health-related characteristics(p<0.05). There was no significant difference in variables of stroke-related characteristics (p>0.05). As variables affecting depression in stroke patients, it was found that depression increased when there was activity restriction(B=3.719), in a married state living alone(B=2.895), and when there was a lot of stress(B=2.824)(p<0.05), and the explanatory power of the regression analysis was 33.7%. Conclusion : In order to maximize the therapeutic effect in establishing occupational therapy intervention strategies for stroke patients with depression, it is thought that it is necessary to add programs for reducing activity restriction, increasing social support, and reducing stress, which are predictive factors for depression in stroke patients.