Objective : This study aims to contribute to developing improved strategies for the rehabilitation programs of stroke patients by analyzing the relationship between obesity, relative grip strength, subjective health status, and health-related quality of life in stroke patients. Method : A secondary analysis was conducted on 651 stroke patients among the raw data from the 6th, second year(2014) to the 8th, first year(2019) of the National Health and Nutrition Examination Survey, in which the grip strength test was conducted. Obesity, relative grip strength, subjective health status, health-related quality of life, and control variables of stroke patients were selected and the relationship between each variable was analyzed. Result : The main results of this study are: First, factors affecting health-related quality of life included subjective health status(β=0.39, p=0.00) and relative grip strength(β=0.28, p=0.00), and obesity have no significant effect. Second, it was confirmed that the interaction between relative grip strength and body mass index showed a positive relationship with health-related quality of life after adjusting for sociodemographic and health behavior factors(β=0.27, p=0.00). Third, the group with high relative grip strength had a significantly higher health-related quality of life than the group with low relative grip strength(F=14.78, p=0.00). Fourth, the group with good subjective health status had significantly higher health-related quality of life than the group with poor subjective health status (F=12.64, p=0.00). Conclusion : Since relative grip strength is a major factor in evaluating the subjective health status and health-related quality of life of stroke patients, an intervention program through strength training, including grip strength training, was attempted to improve the quality of life for patients whose quality of life is expected to decline. In addition, the application of differentiated intervention programs according to the size of relative grip strength in obese group can be a way to improve the health-related quality of life of stroke patients.